Advancing Multi-Scale Simulation Methods for Biological Membrane Systems

Multi-physics and Multi-scale Modelling in Cardiovascular Physiology: Advanced User Methods for Simulation of Biological Systems with ANSYS/CFX

This work encompasses together a number of diverse disciplines (physiology, biomechanics, fluid mechanics and simulation) in order to develop a predictive model of the behaviour of a prosthetic heart valve in vivo. The application of simulation, for the study of other cardiovascular problems, such as blood clotting is also discussed. A commercial, finite volume, computational fluid dynamics (CF...

Stochastic Simulation Methods for Biochemical Systems with Multi-state and Multi-scale Features

An adaptive multi-level simulation algorithm for stochastic biological systems.

Discrete-state, continuous-time Markov models are widely used in the modeling of biochemical reaction networks. Their complexity often precludes analytic solution, and we rely on stochastic simulation algorithms (SSA) to estimate system statistics. The Gillespie algorithm is exact, but computationally costly as it simulates every single reaction. As such, approximate stochastic simulation algor...

tMANS - the Multi-Scale Agent-Based Networked Simulation for the Study of Multi-Scale, Multi-Level Biological and Social Phenomena

We propose a multi-scale agent-based framework towards understanding and modeling multi-scale interdependent behavioral phenomena. This framework combines the ideas of agent-based modeling with that of hierarchies or levels of organization found in nature and allows for multiple levels in the model to interact at various time scales. We first summarize our rationale for pursuing agent-based mod...

Method for Multi-Scale Modeling and Simulation of Assembly Systems

This paper presents the on-going research steps aiming at the development of a Method for Multi-scale Modeling and Simulation of Assembly System. The focus lies on the Assembly System Base Model and its integration into the whole method. After motivating the research, the developed method and the conceived model of the assembly system is introduced, by using the proposed methodology. The presen...